Before i start building a complete news around it, here we go:

First video showed the ingame footage.
Second video an interview with 3D REALMS & ingame footage.

http://www.shacknews.com/onearticle.x/53010

ITīS REAL. After doing news in the past about a little thumbnail picture of Duke Nukem Forever this video is an EVOLUTION. It looks Prey-ish.

Some screens of the video can be found in the 3dRealms Forum:
octobrain, pig cop, 3 barrels chaingun, pipe bomb & tripmines, jet pack, duke vision, holoduke, some weapon icons (rpg), blood, ripper and shrinkray, green goop on the screen.